User blog comment:Sara J Newgate/new orphan/@comment-25942629-20160925115932/@comment-25942629-20160926201751

After the virus strikes, it is reasonable to say that everyone who isn't a child of someone in the upper echelons of the JIDA becomes an orphan. It looks like Yu, Mirai, Shiho, Yoichi, and Tomoe all lost their parents on the night of the Apocalypse. Yu, Shiho, and Yoichi were eight year old then.

I am not understanding your question.

Neither Yu nor Mika started out as orphans right off the bat, but they were experimented on just fine. Being an orphan is not a requirement for experimentation.