Board Thread:General Discussion/@comment-27662189-20160617011117/@comment-25942629-20160617115522

According to the Book of Revelation, there are seven trumpets of the apocalypse. However, Seraph is only loosely based on the Bible, so that could be different for this series. The seraphs clearly have no interest in appearing in numerical order. The Saotome siblings, Kimizuki siblings, Yu, and Mika are all named kids involved in the seraph experiment. There's another seraph experiment kid that Mahiru picks up in the third omnibus, which comes out in September. However, Catastrophe also shows many dotted lines after this list of names, so there should be a ton more involved with the Hyakuya Sect alone. Organizations worldwide were also involved in them, and a short flashback in the manga showed Mika meeting one. Going by a fan translation of the Michaela light novels, it looks like the other kids at Yu and Mika's orphanage were involved as well, although they were not nearly as complete as Yu or Mika.

It also looks like the Horsemen of John that terrorize powerless humans in Vampire Reign and annoy everyone else are the result of experimentation with the Seraph of the End. The first Catastrophe omnibus shows one.

Seraph!Vampire!Mika might be extremely difficult to stop... There is also the question of whether vampires can transform like that since their biology is frozen. If Guren managed to turn Mika human again somehow, he could probably be forced to transform into a full seraph.

During the Apocalypse, the Seraph of the End experiment took a major step forward and killed off 90% of the human population, but the vampires stopped it in the end. All of the named seraph so far have alibi except for the Kimizuki siblings so far, but they both survived and did not kill each other. If they were near each other, there is a very good chance the awakened one would have killed the human one. As long as the seraph part is not active, the awakened seraphs so far have no recognized it. For example, during the battle at Shinjuku, seraph!Yu stabs Mika through the back when he gets in the way and simply calls him a vampire rather than a seraph or Mika. He does not recognize Mika at all. Yu went straight to the nearest human, Shinoa, and tried to kill her. In the anime, he has this random battle with Crowley, but that doesn't make sense with the series. Like the Horsemen, the seraph are only want to kill humans.

When Mirai transforms in the manga, the marks on her skin disappear, so it does not affect seraph. Being part seraph may also be why she survived so long with the infection. In the anime, the markings are still prominent, but that really does not make any sense.

Shiho could certainly be the culprit, but having so many seraphs present makes that really hard to say. Since the vampires stopped it the first time, then they may have killed the seraph responsible. If Shiho did it all, then he might not remember, but Mirai should. Since the Hyakuya members died back then, they may not have been able to erase her memories afterward, and that was probably not their top priority.