Seraph Experiments

Seraph experiments are evident where humans have been tested on to bring the murderous beings within them to the physical world. Initial experiments into the Seraph of the End is believed to be linked to the Catastrophe that devastated the Earth. It is specifically a select number of trumpet wielding seraphs that have successfully been bound. These seraphs are a group of powerful beings whom are being secured and used as living weapons of the Japanese Imperial Demon Army.

Many known human hosts have been secured by the Japanese Imperial Demon Army for angel based experimentation. They are either active officers who managed to access seraphs along with Cursed Gear, or live subjects who have been heavily medicated in order to force both seraph and host into submission as was the case with Mirai Kimizuki. Where experimentation on Mirai had brought out the Fifth Trumpet, that had been prepared for transport as part of Kureto Hīragi's plan to contain the vampires in Nagoya. According to Kureto, they are vital to humanity's survival. In a world where vampires are stronger than humans, as weapons one seraph alone certainly display its effectiveness in a successful campaign to overpower what were stronger foes.

For their significance to the titular In the Seraph of the End series, only a few have been revealed so far. Where they are being gathered by those able, as well as the Fifth Trumpet within Mirai, there is the Sixth Trumpet that had been confined to Guren Ichinose's ancestral home. It would turn out that Yu would be linked to the Second Trumpet.

Background
The Seraph of the End is a magical curse created by human experimentations and then grown inside a person. Some angels were experimented on by the Hyakuya Sect prior to the apocalypse. Both the Hyakuya Sect and Japanese Imperial Demon Army erased the memories of the experimentation from their test subjects. Other surviving human organizations around the world have experimented on the Seraph of the End, but even their cruelty is said to pale in comparison to the that of the Japanese Imperial Demon Army.

Guren Ichinose has been experimenting on them as well where one was kept restrained at his residence. In the Catastrophe light novels, it would be the case that Mahiru Hīragi brought Guren Ichinose some documents listing the Seraph of the End subjects. Guren collected at least four of them before betraying them during the Nagoya Airport experiment in the Vampire Reign manga series. Guren has been involved in the transformation of at least two of them thus far.

Mikaela Hyakuya has been on missions overseas to destroy the surviving cult groups. The test subjects often scream or even beg for death prior to their transformations. So far, all of the humans tested are capable of handling the Black Demon Series weapons. Kureto succeeds in controlling the Fifth Trumpet for a period of time by making many sacrifices and using the demon Abaddon for possession.

Taboo
According to Ferid Bathory, the experiment "Seraph of the End" is actually an experiment to revive the dead. According to vampire belief, the humans committed a taboo, currently believed to be reviving the dead, which triggers the appearance of an angel of destruction. This is the reason the vampires conquered the world from underground and crushed any organizations working on that experiment. However, the Demon Army has since learned how to control these angels for themselves.

Ferid mentions that Guren completed the experiment and triggered the Apocalypse when he revived his deceased friends, Shinya Hīragi, along with Mito Jūjō, then Norito Goshi, with Shigure Yukimi, and Sayuri Hanayori without their knowledge. This experiment caused the virus that killed off most of the adult population. The five revived individuals appear to have no knowledge of dying and have continued to age and grow since then. At first it was uncertain whether Ferid was telling the truth or not, until he confirms Guren's act.

It is gathered that in breaking a taboo, such as reviving the dead, then the seraph of the end is the weapon that controls and directs the divine retribution. The idea of controlling seraphs to break the taboo with a price not addressed, Guren affirms it is not nearly so convenient and there is a stupidly massive price. Resurrecting the dead is a curse, and if Kimizuki, along with Yoichi, then Yu and Mika want to bring their families back, then they will wind up cursed like Guren too.

Nature
Generally, where they pay no mind to vampires and are not too concerned with demons, seraphs when conscious are extremely hostile to humans and seek their destruction without delay. Like the Horsemen of the Apocalypse, the seraphs strive to kill all humans the world over. The seraph humans speak in archaic language and have no recollection of their human identities.

In the Sixth Trumpet's transformation being reversed by the demon power boosting injection, a cross shaped dagger flew out of his chest, his wings dissolve, and the black liquid stops flowing from his eye. As for the cross shaped dagger, Saitō is shown having two of the exact same objects in his possession, but it does not state whether these two were also from seraphs that turned back into humans like the Sixth Trumpet or not, and it is unknown on what exact purpose they serve. The only clue is Guren saying that the object is being taken to Tokyo for humanity to fight against millennia old monsters.

Appearance
The appearances of the seraphs in their transformed states vary to various degrees, but they all appear to have a wing or wings. It is unclear if this is related to their suitability to the experimentation, what proportion of their body is considered seraph, or which type of experimentation has been performed on them.

For the completely awakened seraphs that have appeared in the story are, for Mirai with the Fifth Trumpet, they have two exceptionally large pairs of feathered wings from her back. A signature seraph trait is the physical giant trumpet floating beneath her. The curse marks on her skin from the apocalypse virus disappear when the seraph is active. In the anime, the opposite happens and the number of markings increase despite the fact the virus has no reason to effect an angel. When Abaddon possesses Mirai, the demon manifests in a giant dark figure with many wings behind her and is partially formless.

Yu, the Second Trumpet, has dark sclera and a single pair of irregular black wings once he completely transforms. This is because his demon, Asuramaru, was wrestling control with the seraph in an attempt to stop them from fully taking over. This is why Mirai's wings are avian-like where they are feather based, yet Yu's wings are blackened. In a flashback, Mika recalls an undernourished seraph child held in a fluid-filled tank with a mask on the face to supply air. The child had feathered wings for arms.

First Trumpet
No information.

Second Trumpet
By using a certain substance added to his cursed gear stimulants, Guren unleashes the seraph characteristics within Yūichirō Hyakuya for a few minutes during the battle at Shinjuku. When the stimulant takes affect, Yu cries out and loses his mind as he undergoes a painful transformation. His left eye turns dark and bleeds while a massive black wing-like structure sprouts from his upper right shoulder. Although extremely powerful, Yu goes berserk and attempts to kill any human nearby. He displays no interest in vampires and recognizes no one as he mutters about killing sinners.

After ingesting three of the standard Japanese Imperial Demon Army supplements, Yu's internal organs rupture, including his heart. However, the power of the seraphs prevents Yu from dying. Asuramaru cautions him that angels can be far nastier than demons. After this event, Yu loses more of his humanity and is implied to become proportionally more seraph-like in the process.

During the battle at the airport in Nagoya, Yu becomes desperate after Guren succumbs to possession and Mirai transforms into the Fifth Trumpet to purge humanity. After fainting mid-sentence from the severe injuries Guren gives him, Yu acquires the trumpet within his mind and disregards Asuramaru's warning that this will erase the remainder of his humanity.

Screaming, Yu becomes surrounded by a pillar of fire upon his transformation. Where two irregular black wings are formed, Yu's sclera also become dark. Flying freely in this form, Yu curses the tainted humans and threatens to turn them into "pillars of salt." Yu easily summons and manipulates vast quantities of salt at will; for example, in the anime he was seen transforming a large volume of salt into a spear. After appearing, Yu attacks the demon Abaddon and disrupts its manifestation.

One Demon Army soldier refers to the second trumpet as the "King of Salt". Once the angel turns his attention to the humans, Asuramaru convinces Yu to become a full demon while Guren encourages the action from below. Horns appear, and Yu uses Asuramaru's blade to stab himself through the chest after he screams about saving his family.

In order to prepare for the battle against Ky Luc, time is used when Guren trains Yu to control his seraph by making the presence within Yu go berserk repeatedly. Three days later, when fighting the fifth progenitor, Yu becomes a partial seraph again, but now has fangs due to Asuramaru's influence. On account of his seraph powers, Yu is able to regenerate his chest that was essentially blown out.

Following the battle, Yu is seen in his mind kneeling as he recovers from the strain of the seraph power. Commenting on Yu's clawed hand holding the angel's trumpet, Asuramaru revealed it was the result of the substances needed to keep the seraph under control. He also states that Yu's body is still being taken over by a demon.

It is shown Yu had seraph genes ever since the dark ages of Greece. As a child, Yu as a seraph had white feathered wings since there was no demon to affect them. He first displayed the murderous streak towards humans though not Sika Madu. It was to the extent that Yu in this state proceeded to sever his own arm in order to reach a human. Capable of flight, Yu would consider how all humans needed to die. It appeared that these seraph traits were being moulded by the influence of a black sun.

Third Trumpet
No information.

Fourth Trumpet
No information.

Fifth Trumpet
On the way to Nagoya, Kureto Hīragi has Mirai Kimizuki injected with chemicals to force her to transform. She screams and begs for death until two pairs of white feathered wings sprout from her back.

At the point in time it would transpire that Kureto is planning to control an angel, which no one has ever successfully done before. According to Mahiru-no-Yo (who is possessing Guren at the moment), "blood is needed to control the angel." During the Nagoya Airport experiment, Kureto, along with Guren, and Mahiru-no-Yo sacrifice many humans, vampires, and demons to bind Mirai and use their blood to control her after using Abaddon to possess her. This appears to be successful, but the Second Trumpet awakens and destroys Abaddon's manifestation. The Fifth Trumpet is apparently sealed to leave Mirai unconscious.

Three months later, Mirai herself is still under Kureto's control as she is used to destroy the underground vampire city of Sanguinem in a major victory for humanity. Also later dispatched to Shibuya, the Fifth Trumpet is kept at a distance while Kureto sets about overthrowing his father Tenri Hīragi. With Abaddon above, the Fifth Trumpet adheres to the command to fire at a barrier Aoi Sangū set up, where the emission successfully makes contact with Tenri to secure victory.

Ordered to attack Shikama Dōji when he appeared, the Fifth Trumpet and Abaddon prepared their attack, before immediately complying with the First's command to stop. The seraph experiment is referred to as Shikama Doji's who voices shock that it was thought that could damage him. Mirai then ends up with a single pair of wings after the appearance of Shikama Dōji.

When Shibuya comes under attack by the Hyakuya Sect, the Fifth Trumpet's wings appear out of Mirai, yet is motionless in between Kimizuki, also Saitō and the First who is possessing Shinoa Hīragi's body. Carried away, Mirai would be unconscious where the Fifth Trumpet would not react to her being stabbed by Guren. With that done, a Sinful Key emerged from Mirai's body.

Sixth Trumpet
The unnamed Sixth Trumpet is introduced imprisoned inside a magical barrier within the underground laboratory of Guren's former mansion in the Aichi Prefecture. Guren claims that the Sixth Trumpet is one of Yu's comrades, and is identified as male.

As with the Fifth Trumpet, the Sixth Trumpet has two pairs of white feathered wings. He has the power to summon Horsemen of the Apocalypse to the world, as Guren reveals to Yu and Mikaela Hyakuya that he has been summoning them onto this world for the past eight years. The Horsemen can be fired as projectiles from the youth's hands that will form into the monsters, and also emerge at seemingly random locations across the vast area of a forest.

When asked by Yu if he has been crying for all these years, the Sixth Trumpet avoids the subject and questions Yu in turn, "Why won't you destroy this world?" Concluding that Yu is not fit to be an angel, the Sixth Trumpet attempts to kill him so that a new King of Salt shall be born. Summoning Horsemen to attack Yu and everyone, with the chains restraining him gone, the seraph takes the fight to the sky.

In an exchange between Yu and Asuramaru during the fight, it is revealed that the Sixth Trumpet has a demon inside of him. Eventually, the Sixth Trumpet gets pinned down by Yu with his trumpet knocked away by Mika, for Kimizuki to inject him with a pacifying substance. Consequently, the youth floats downwards for the first seen at that time cross shaped dagger to fly out of his chest. The youth then plummets to the ground as his wings dissolve before being caught by Kimizuki, where he now appeared as a normal human. With the Sixth Trumpet sealed, this also puts an end to the Horsemen of the Apocalypse across the entire world which vanish from it.

Seventh Trumpet
No information.

People known to possess the seraph gene

 * Yūichirō Amane - Second Trumpet, "The Devil", "King of Salt" (Active)
 * Awakens in an incomplete form for a few minutes after taking a special drug created by Guren. Shinoa's embrace returns him to his human form, but he remains in a coma for a week afterward and does not recall the transformation.
 * Asuramaru informs Yu that he is even less human than before after he fatally overdoses on the Demon Army drugs and has his life maintained by the power of angels.
 * Completely awakens as the 2nd Trumpet and King of Salt after erasing the rest of his humanity. He becomes a full demon in order to suppress the angel's power.
 * Later, Yu trains under Guren to get the seraph under control by injecting himself with a drug that turns him into it until Yu gets calmed down. Three days later Yu, with Asuramaru's help, is able to control himself as a seraph when fighting Fifth Progenitor Ky Luc.
 * Yu becomes the King of Salt again in order to fight the 6th Trumpet and lasts after injecting the 6th with the drug.


 * Mikaela Shindō (Inactive)
 * It is not known what number Mika's Seraph has, but it is known that his name is "Angel Mikaela".
 * It was said that in addition to "Seraph gene", Mika also has "Michaela gene".
 * The Seraphim has six wings that appeared when Mika came into contact with an entity.
 * Mika's Seraph is most likely related to Sika Madu's son, Mikaela.


 * Shihō Kimizuki (Inactive)
 * In the light novels, it is confirmed he and his sister are also results of the "Seraph of the End" experiments the Hyakuya Sect undertook.


 * Mirai Kimizuki - Fifth Trumpet, "Angel of Destruction" (Deceased)
 * During the battle in Nagoya, the Demon Army injects drugs into Mirai that causes her great agony until she sprouts two pairs of white wings.
 * The Demon Army releases her onto the battlefield and then uses the demon Abaddon and their curses to bind and possess her.
 * Abaddon's manifestation is disrupted by the Second Trumpet that awakens.
 * Three months later, the Fifth Trumpet aids the Demon Army in attacking Sanguinem.
 * Kureto Hīragi has the seraph attack Shibuya as part of his coup against his father, Tenri Hīragi. It destroys Tenri's lower half with Abaddon.
 * With the appearance of Shikama Dōji, the Fifth Trumpet is seen with two wings when preparing to attack him with Abaddon only for Shikama to stop it with a simple command.
 * Kept within a room in the Demon Army's lab, she is injected in the neck with a drug on Kureto's orders to activate her as a seraph and four seraph wings emerge from her back.
 * She is unresponsive when situated in between Saitō and Shikama Dōji who has possessed Shinoa's body. Mirai also does not react when she is taken by her brother who escapes whilst Saitō distracts the first.
 * Carried unconscious on her brother's back, Mirai does not acknowledge the ruin occurring in the city, neither when she is stabbed through the chest by Guren. As Mirai is dropped to the ground, a sinful key erupts from her and her seraph wings disappear.
 * Her deceased body is transported away from Demon Army territory and kept in a refrigerator. There are no signs of degradation, speculated to be because of all the experiments she went through.


 * Unnamed boy - Sixth Trumpet


 * Yoichi Saotome (Inactive)
 * In the light novels, it is confirmed he and his sister are also results of the "Seraph of the End" experiments the Hyakuya sect undertook.


 * Tomoe Saotome (Inactive, deceased)
 * In the light novels, it is confirmed she and her brother are also results of the "Seraph of the End" experiments the Hyakuya sect undertook. Tomoe's body had been taken to an underground facility in Akihabara to await resurrection.

Abilities
So far, three full Seraphs have made an appearance in the story. According to the manga, the abilities of each Seraph is different as they are based on the number of their Trumpet. Yu under the influence of the Second Trumpet is shown to have heightened physical abilities and the power to turn his enemies into salt. The unnamed Sixth Trumpet is able to summon Horsemen. Mirai is shown to summon the Horsemen as well.

Seraphs are shown to be able to heal their hosts and keep them alive despite fatal wounds, such as Mirai being cured of the apocalypse virus, and Yu being kept alive after he took three cursed gear stimulants, despite all of his internal organs being ruptured already.

Some of the seraphs have abilities loosely related to those listed in Revelation chapters 8 through 9 in the New Testament of the Bible and are referred to by their trumpets.

Powers

 * Waves of salt: a flood of salt can turn all upon contact into the substance to disintegrate them entirely.
 * Summoning Four Horsemen of John: Multiple numbers of these beings could fully form in a short time across a large area and be ready to attack anything nearby.

Owari no Seraph.Com
Seraph related images that were on Owari no Seraph.Com.

Trivia

 * The term "seraph" refers to a type of angel.