Seraph Experiments

Seraph experiments are evident where humans have been tested on to bring the murderous beings within them to the physical world. Initial experiments into the Seraph of the End is believed to be linked to the Catastrophe that devastated the Earth. It is specifically a select number of trumpet wielding seraphs that have successfully been bound. These seraphs are a group of powerful beings whom are being secured and used as living weapons of the Japanese Imperial Demon Army.

Many known human hosts have been secured by the Japanese Imperial Demon Army for angel based experimentation. They are either active officers who managed to access seraphs along with Cursed Gear, or live subjects who have been heavily medicated in order to force both seraph and host into submission as was the case with Mirai Kimizuki. Where experimentation on Mirai had brought out the Fifth Trumpet, that had been prepared for transport as part of Kureto Hīragi's plan to contain the vampires in Nagoya. According to Kureto, they are vital to humanity's survival. In a world where vampires are stronger than humans, as weapons one seraph alone certainly displays its effectiveness in a successful campaign to overpower what were stronger foes.

For their significance to the titular In the Seraph of the End series, only a few have been revealed so far. Where they are being gathered by those able, as well as the Fifth Trumpet within Mirai, there is the Sixth Trumpet that had been confined to Guren Ichinose's ancestral home. It would turn out that Yu would be linked to the Second Trumpet. In a dream world, Mika was seen to have angelic wings.

Background
The Seraph of the End is a magical curse created by human experimentations and then grown inside a person. Some angels were experimented on by the Hyakuya Sect prior to the apocalypse. Both the Hyakuya Sect and Japanese Imperial Demon Army erased the memories of the experimentation from their test subjects. Other surviving human organizations around the world have experimented on the Seraph of the End, but even their cruelty is said to pale in comparison to the that of the Japanese Imperial Demon Army.

Guren Ichinose has been experimenting on them as well where one was kept restrained at his residence. In the Catastrophe light novels, it would be the case that Mahiru Hīragi brought Guren Ichinose some documents listing the Seraph of the End subjects. Guren collected at least four of them before betraying them during the Nagoya Airport experiment in the Vampire Reign manga series. Guren has been involved in the transformation of at least two of them thus far.

Mika has been on missions overseas to destroy the surviving cult groups. The test subjects often scream or even beg for death prior to their transformations. So far, all of the humans tested are capable of handling the Black Demon Series weapons. Kureto succeeds in controlling the Fifth Trumpet for a period of time by making many sacrifices and using the demon Abaddon for possession.

In the Sixth Trumpet's transformation being reversed by the demon power boosting injection, a cross shaped dagger flew out of his chest, his wings dissolve, and the black liquid stops flowing from his eye. As for the cross shaped dagger, Saitō is shown having two of the exact same objects in his possession, but it does not state whether these two were also from seraphs that turned back into humans like the Sixth Trumpet or not, and it is unknown on what exact purpose they serve. The only clue is Guren saying that the object is being taken to Tokyo for humanity to fight against millennia old monsters.

Appearances
The appearances of the human in their seraphs influenced states vary to various degrees, but they all appear to have a wing or wings. It is unclear if this is related to their suitability to the experimentation, what proportion of their body is considered seraph, or which type of experimentation has been performed on them.

For the completely awakened seraphs that have appeared in the story are, for Mirai with the Fifth Trumpet, they have two exceptionally large pairs of feathered wings from her back. A signature seraph trait is the physical giant trumpet floating beneath her. The curse marks on her skin from the apocalypse virus disappear when the seraph is active. In the anime, the opposite happens and the number of markings increase despite the fact the virus has no reason to effect an angel. When Abaddon possesses Mirai, the demon manifests in a giant dark figure with many wings behind her and is partially formless.

Yu, the Second Trumpet, has dark sclera and a single pair of irregular black wings once he completely transforms. This is because his demon, Asuramaru, was wrestling control with the seraph in an attempt to stop them from fully taking over. This is why Mirai's wings are avian-like where they are feather based, yet Yu's wings are blackened. In a flashback, Mika recalls an undernourished seraph child held in a fluid-filled tank with a mask on the face to supply air. The child had feathered wings for arms.

Yūichirō Amane

 * Second Trumpet, "The Devil", "King of Salt" (Active)
 * Awakens in an incomplete form for a few minutes after taking a special drug created by Guren. Shinoa's embrace returns him to his human form, but he remains in a coma for a week afterward and does not recall the transformation.
 * Asuramaru informs Yu that he is even less human than before after he fatally overdoses on the Demon Army drugs and has his life maintained by the power of angels.
 * Completely awakens as the 2nd Trumpet and King of Salt after erasing the rest of his humanity. This was done to fight against Abaddon and the Fifth Trumpet. He becomes a full demon in order to suppress the angel's power.
 * Later, Yu trains under Guren to get the seraph under control by injecting himself with a drug that turns him into it until Yu gets calmed down. Three days later Yu, with Asuramaru's help, is able to control himself as a seraph when fighting Fifth Progenitor Ky Luc.
 * Yu becomes the King of Salt again in order to fight the 6th Trumpet and lasts after injecting the 6th with the drug.

Mikaela Shindō

 * (Inactive)
 * It is not known what number Mika's Seraph has, but it is known that his name is "Angel Mikaela".
 * It was said that in addition to "Seraph gene", Mika also has "Michaela gene".
 * The Seraphim has six wings that appeared when Mika came into contact with an entity.
 * Mika's Seraph is most likely related to Sika Madu's son, Mikaela. It is speculated that Mika as meant as a biological container for Mikaela's spirit.

Shihō Kimizuki

 * (Inactive)
 * It is confirmed he and his sister Mirai are also results of the "Seraph of the End" experiments the Hyakuya Sect undertook.

Mirai Kimizuki

 * Fifth Trumpet, "Angel of Destruction" (Deceased)
 * During the battle in Nagoya, the Demon Army injects drugs into Mirai that causes her great agony until she sprouts two pairs of white wings.
 * The Demon Army releases her onto the battlefield and then uses the demon Abaddon and their curses to bind and possess her.
 * Abaddon's manifestation is disrupted by the Second Trumpet that awakens.
 * Three months later, the Fifth Trumpet aids the Demon Army in attacking Sanguinem.
 * Kureto Hīragi has the seraph attack Shibuya as part of his coup against his father, Tenri Hīragi. It destroys Tenri's lower half with Abaddon.
 * With the appearance of Shikama Dōji, the Fifth Trumpet is seen with two wings when preparing to attack him with Abaddon only for Shikama to stop it with a simple command.
 * Kept within a room in the Demon Army's lab, she is injected in the neck with a drug on Kureto's orders to activate her as a seraph and four seraph wings emerge from her back.
 * She is unresponsive when situated in between Saitō and Shikama Dōji who has possessed Shinoa's body. Mirai also does not react when she is taken by her brother who escapes whilst Saitō distracts the first.
 * Carried unconscious on her brother's back, Mirai does not acknowledge the ruin occurring in the city, neither when she is stabbed through the chest by Guren. As Mirai is dropped to the ground, a sinful key erupts from her and her seraph wings disappear.
 * Her deceased body is transported away from Demon Army territory and kept in a refrigerator. There are no signs of degradation, speculated to be because of all the experiments she went through.

Unnamed boy

 * Sixth Trumpet
 * Kept within Guren's residence the Sixth Trumpet was active in this youth's body and had been summoning Horsemen of the Apocalypse to the world.
 * The seraphs regarding Yu as a faulty seraph and meant to kill him to bring a new King of Salt into the world.
 * It physically attacked Yu using the large trumpet it carried rather than resort to the powers at its disposal.

Yoichi Saotome

 * (Inactive)
 * It is confirmed he and his sister Tomoe are also results of the "Seraph of the End" experiments the Hyakuya sect undertook.

Tomoe Saotome

 * (Inactive, deceased)
 * It is confirmed she and her brother are also results of the "Seraph of the End" experiments the Hyakuya sect undertook.
 * For any seraph possibly becoming active, Tomoe's deceased body had been taken to an underground facility in Akihabara to await resurrection.

Involved Beings
While seraph experiments in name, it would transpire that there were a large number of these beings in the past. Rather than on any of these, it would seem that it was a specific set of seraphs that were either around by present times or able to be experimented on at such points.
 * Seraphs

It appeared the case that more prominent seraphs could assume a humanoid appearance using Photons, and event seen in the prehistoric past. It does not seem the case that human-like angels were a part of the seraph experiments.
 * Human Appearing Angels

It is this final group were seemingly the ones involved in seraph experiments by organizations of the present day. It transpires that bearing a trumpet is not a common occurrence for a seraph. Accordingly, this criteria may have been a requirement for the most notable seraph experiments.
 * Trumpets of the Apocalypse

Abilities
So far, three active seraph experiments have made an appearance. It would appear that the abilities of each Seraph is different as they are based on the number of their Trumpet. Yu under the influence of the Second Trumpet is shown to have heightened physical abilities and the power to turn his enemies into salt. The unnamed Sixth Trumpet is able to summon Horsemen. Mirai is shown to summon the Horsemen as well.

Seraphs are shown to be able to heal their hosts and keep them alive despite fatal wounds. Mirai was able to be cured of the apocalypse virus, Yu could be kept alive after he took three cursed gear stimulants, despite all of his internal organs being ruptured already.

Some of the seraphs have abilities loosely related to those listed in Revelation chapters 8 through 9 in the New Testament of the Bible and are referred to by their trumpets.

Powers

 * Waves of salt: a flood of salt can turn all upon contact into the substance to disintegrate them entirely.
 * Summoning Four Horsemen of John: Multiple numbers of these beings could fully form in a short time across a large area and be ready to attack anything nearby.

Owari no Seraph.Com
Seraph related images that were on Owari no Seraph.Com.

Trivia

 * The term "seraph" refers to a type of angel.