Horsemen of the Apocalypse

The Horsemen of the Apocalypse, also known as the Four Horsemen of John (ヨハネの四騎士,), are monsters created by the Hyakuya Sect. Their first reveal was at a zoo in the summer of 2012, the summer prior to Armageddon, and Kureto Hīragi sent Guren Ichinose Squad to investigate it.

Details
Horsemen are large non-sentient creatures with many wings and legs, although they have not been shown to fly. They attack to kill any human they notice and take no interest in vampires or animals. This excludes the special horsemen that were summoned by Abaddon to kill the army of vampires and humans.

The Japanese Imperial Demon Army uses a barrier around their city walls to drastically weaken the horsemen when they come within a kilometer of the barrier.
 * "Horsemen only attack humans. Almost as if they were sent to cull the world's bloated human population."--Shinoa, Chapter 8, "Mitsuba's Squad"

Story
Yūichirō Hyakuya encounters Horsemen of the Apocalypse during his assignment as a private in Shinjuku. In chapter 2, he attacks and kills one against orders, and it is stated he has done this many times before. As punishment for his insubordination, he is sentenced to attend high school classes until he can make a friend.

When arriving at Harajuku Station, Shinoa Squad spots a young girl being chased by a Horseman of the Apocalypse. She and Mitsuba explain that this is a trap by the vampires, and the child is the bait because she would not be able to survive on her own in this world. When Shiho Kimizuki asks how the vampires are giving orders to the Horsemen, Shinoa explains that Horsemen are non-sentient and only attack any nearby humans. Yu disobeys orders once again and rescues the child by throwing her to his squad members. Three vampires take that opportunity to attack him. Kimizuki, Yoichi, and Mitsuba step in the kill the Horseman, and Mitsuba has the finishing blow.

When Mikaela Hyakuya arrives at Sannomiya, Kobe, he kills a Horseman of the Apocalypse to save a human girl as she flees for her life. The rescued population of humans gratefully become vampire livestock.

As Shinoa Squad drives down the Tomei Expressway on their way to the Ebina Rest Stop, they encounter three Horsemen. Yu jumps out and kills them with one strike when they notice him and leap at him. Shinoa and Mitsuba then prank Yu by leaving him behind in the middle of the road. They let him walk for ten minutes before they pick him up again.

Trivia
In Christian beliefs, The Four Horsemen of the Apocalypse are referenced in the Book of Revelation as warriors meant to end the world.